Assay Detail
Binding
CHEMBL828410
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Inhibition of phosphodiesterase 1
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.88 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL369081 | — | — | 1 | 8.00 |
| CHEMBL183857 | — | — | 1 | 8.00 |
| CHEMBL361582 | — | — | 1 | 8.00 |
| CHEMBL434135 | — | — | 1 | 8.00 |
| CHEMBL182179 | — | — | 1 | 7.70 |
| CHEMBL179849 | — | — | 1 | 7.52 |
| CHEMBL183150 | — | — | 1 | 7.52 |
| CHEMBL183696 | — | — | 1 | 7.52 |
| CHEMBL180994 | — | — | 1 | 7.40 |
| CHEMBL182829 | — | — | 1 | 7.30 |
| CHEMBL181916 | — | — | 1 | 7.30 |
| CHEMBL359924 | — | — | 1 | 6.70 |
| CHEMBL444354 | — | — | 1 | 6.70 |
| CHEMBL168949 | — | — | 1 | 6.52 |
| CHEMBL352722 | — | — | 1 | 6.52 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 6.40 |
| CHEMBL359944 | — | — | 1 | 6.30 |
| CHEMBL183877 | — | — | 1 | 6.30 |
| CHEMBL54079 | — | — | 1 | 6.10 |
| CHEMBL361864 | — | — | 1 | 6.10 |
| CHEMBL360508 | — | — | 1 | 6.00 |
| CHEMBL182895 | — | — | 1 | 6.00 |
| CHEMBL182712 | — | — | 1 | 6.00 |
| CHEMBL183370 | — | — | 1 | 6.00 |
| CHEMBL361136 | — | — | 1 | 6.00 |
| CHEMBL183096 | — | — | 1 | - |
| CHEMBL360086 | — | — | 1 | - |
| CHEMBL183343 | — | — | 1 | - |
| CHEMBL414842 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL369081 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL183857 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL361582 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL434135 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL182179 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL179849 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL183150 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL183696 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL180994 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL182829 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL181916 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL359924 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL444354 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL168949 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL352722 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL359944 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL183877 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL54079 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL361864 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL360508 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL182895 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL182712 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL183370 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL361136 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL183096 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL360086 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL183343 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL414842 | — | IC50 | > | 1000.0 | nM | - |