Assay Detail
Binding
CHEMBL828424
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Inhibition of [3H]mibolerone binding to human Androgen receptor of PC3/AR Cell Lysate
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.19 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146858 | — | — | 1 | 8.22 |
| CHEMBL1274 | NILUTAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL2113036 | — | — | 1 | 7.31 |
| CHEMBL386437 | — | — | 1 | 7.20 |
| CHEMBL2113034 | — | — | 1 | 7.11 |
| CHEMBL264131 | — | — | 1 | 7.05 |
| CHEMBL806 | FLUTAMIDE | 4.0 | 1 | 6.81 |
| CHEMBL2113032 | — | — | 1 | 6.48 |
| CHEMBL347556 | — | — | 1 | 6.46 |
| CHEMBL147457 | — | — | 1 | - |
| CHEMBL27577 | SALICYLAMIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146858 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1274 | NILUTAMIDE | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2113036 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL386437 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2113034 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL264131 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL806 | FLUTAMIDE | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL2113032 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL347556 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL147457 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL27577 | SALICYLAMIDE | IC50 | >> | 1000.0 | nM | - |