Assay Detail
Binding
CHEMBL828545
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In vitro inhibitory concentration against COX-1 enzyme
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.35 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 6.52 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.54 |
| CHEMBL373231 | — | — | 1 | - |
| CHEMBL195388 | — | — | 1 | - |
| CHEMBL192558 | — | — | 1 | - |
| CHEMBL434725 | — | — | 1 | - |
| CHEMBL192081 | — | — | 1 | - |
| CHEMBL448156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL25 | ASPIRIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL373231 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL195388 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL192558 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL434725 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL192081 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL448156 | — | IC50 | > | 100000.0 | nM | - |