Assay Detail
Binding
CHEMBL828863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]spiperone binding to rat dopamine D2 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.41 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426763 | — | — | 1 | 9.37 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.32 |
| CHEMBL180319 | — | — | 1 | 8.08 |
| CHEMBL367045 | — | — | 1 | 7.76 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.16 |
| CHEMBL179557 | — | — | 1 | 7.15 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.60 |
| CHEMBL179775 | — | — | 1 | 6.24 |
| CHEMBL178564 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426763 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL180319 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL367045 | — | Ki | = | 17.2 | nM | 7.76 |
| CHEMBL715 | OLANZAPINE | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL179557 | — | Ki | = | 71.1 | nM | 7.15 |
| CHEMBL42 | CLOZAPINE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL179775 | — | Ki | = | 578.0 | nM | 6.24 |
| CHEMBL178564 | — | Ki | = | 923.0 | nM | 6.04 |