Assay Detail
Binding
CHEMBL828894
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Opioid receptor mu 1 expressed in CHO cells using [3H]DAMGO as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.17 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426084 | SAMIDORPHAN | 4.0 | 1 | 10.28 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.96 |
| CHEMBL370029 | — | — | 1 | 9.89 |
| CHEMBL56695 | — | — | 1 | 9.15 |
| CHEMBL195285 | — | — | 1 | 7.96 |
| CHEMBL195787 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426084 | SAMIDORPHAN | Ki | = | 0.052 | nM | 10.28 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL370029 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL56695 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL195285 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL195787 | — | Ki | = | 17.0 | nM | 7.77 |