Assay Detail
Binding
CHEMBL828910
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Binding affinity for human factor Xa
33
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and X-ray crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 8.36 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191394 | — | — | 1 | 10.15 |
| CHEMBL364268 | — | — | 1 | 10.00 |
| CHEMBL190142 | — | — | 1 | 9.60 |
| CHEMBL279212 | — | — | 1 | 9.52 |
| CHEMBL189587 | — | — | 1 | 9.52 |
| CHEMBL190335 | — | — | 1 | 9.15 |
| CHEMBL190599 | — | — | 1 | 9.00 |
| CHEMBL188275 | — | — | 1 | 9.00 |
| CHEMBL430300 | — | — | 1 | 8.70 |
| CHEMBL190471 | — | — | 1 | 8.70 |
| CHEMBL370959 | — | — | 1 | 8.70 |
| CHEMBL190913 | — | — | 1 | 8.70 |
| CHEMBL363753 | — | — | 1 | 8.52 |
| CHEMBL188693 | — | — | 1 | 8.52 |
| CHEMBL364007 | — | — | 2 | 8.52 |
| CHEMBL434356 | — | — | 1 | 8.52 |
| CHEMBL182746 | — | — | 1 | 8.52 |
| CHEMBL189311 | — | — | 1 | 8.30 |
| CHEMBL188661 | — | — | 1 | 8.15 |
| CHEMBL191480 | — | — | 1 | 8.15 |
| CHEMBL371820 | — | — | 1 | 8.15 |
| CHEMBL364696 | — | — | 1 | 8.05 |
| CHEMBL190694 | — | — | 1 | 8.05 |
| CHEMBL190839 | — | — | 1 | 7.75 |
| CHEMBL189949 | — | — | 1 | 7.70 |
| CHEMBL350963 | — | — | 1 | 7.64 |
| CHEMBL190386 | — | — | 1 | 7.60 |
| CHEMBL190378 | — | — | 1 | 7.58 |
| CHEMBL189981 | — | — | 1 | 7.26 |
| CHEMBL182323 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191394 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL364268 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL190142 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL279212 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL189587 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL190335 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL188275 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL190599 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL430300 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL190471 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL370959 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL190913 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL188693 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL182746 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL364007 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL364007 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL363753 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL434356 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL189311 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL191480 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL188661 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL371820 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL190694 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL364696 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL190839 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL189949 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL350963 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL190386 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL190378 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL189981 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL182323 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL360192 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL363143 | — | Ki | = | 835.0 | nM | 6.08 |