Assay Detail
Binding
CHEMBL828927
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Binding affinity against rat 5-hydroxytryptamine 2A receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.35 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74355 | VOLINANSERIN | 3.0 | 1 | 10.00 |
| CHEMBL145939 | — | — | 1 | 9.74 |
| CHEMBL176109 | — | — | 1 | 9.52 |
| CHEMBL177807 | — | — | 1 | 9.29 |
| CHEMBL175832 | — | — | 1 | 9.20 |
| CHEMBL368816 | — | — | 1 | 8.88 |
| CHEMBL178055 | — | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74355 | VOLINANSERIN | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL145939 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL176109 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL177807 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL175832 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL368816 | — | Ki | = | 1.33 | nM | 8.88 |
| CHEMBL178055 | — | Ki | = | 1.6 | nM | 8.80 |