Assay Detail
Binding
CHEMBL829188
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Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | C2C12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.56 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372684 | — | — | 1 | 8.52 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.47 |
| CHEMBL310570 | — | — | 1 | 8.08 |
| CHEMBL82546 | — | — | 1 | 7.77 |
| CHEMBL364015 | — | — | 1 | 7.64 |
| CHEMBL193404 | — | — | 1 | 7.47 |
| CHEMBL362914 | — | — | 1 | 6.58 |
| CHEMBL195972 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372684 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL131 | PREDNISOLONE | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL310570 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL82546 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL364015 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL193404 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL362914 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL195972 | — | EC50 | = | 1209.0 | nM | 5.92 |