Assay Detail
Binding
CHEMBL829309
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Inhibition of rat c-Jun N-terminal kinase 3
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mitogen-activated protein kinase 10 (CHEMBL4092) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 6.13 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363355 | — | — | 1 | 7.39 |
| CHEMBL363254 | — | — | 1 | 7.19 |
| CHEMBL372708 | — | — | 1 | 7.10 |
| CHEMBL191581 | — | — | 1 | 7.10 |
| CHEMBL1788116 | — | — | 1 | 6.92 |
| CHEMBL371113 | — | — | 1 | 6.84 |
| CHEMBL189841 | — | — | 1 | 6.83 |
| CHEMBL364757 | — | — | 1 | 6.60 |
| CHEMBL364637 | — | — | 1 | 6.60 |
| CHEMBL363253 | — | — | 1 | 6.56 |
| CHEMBL189852 | — | — | 1 | 6.47 |
| CHEMBL190742 | — | — | 1 | 6.47 |
| CHEMBL425902 | — | — | 1 | 6.46 |
| CHEMBL189223 | — | — | 1 | 6.40 |
| CHEMBL191376 | — | — | 1 | 6.39 |
| CHEMBL365963 | — | — | 1 | 6.34 |
| CHEMBL424815 | — | — | 1 | 6.33 |
| CHEMBL191204 | — | — | 1 | 6.30 |
| CHEMBL190597 | — | — | 1 | 6.29 |
| CHEMBL370889 | — | — | 1 | 6.23 |
| CHEMBL190250 | — | — | 1 | 6.22 |
| CHEMBL364940 | — | — | 1 | 6.19 |
| CHEMBL191465 | — | — | 1 | 6.18 |
| CHEMBL191021 | — | — | 1 | 6.15 |
| CHEMBL370899 | — | — | 1 | 6.12 |
| CHEMBL191269 | — | — | 1 | 6.09 |
| CHEMBL370477 | — | — | 1 | 6.02 |
| CHEMBL363155 | — | — | 1 | 6.00 |
| CHEMBL425553 | — | — | 1 | 5.89 |
| CHEMBL370960 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363355 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL363254 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL191581 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL372708 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1788116 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL371113 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL189841 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL364757 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL364637 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL363253 | — | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL189852 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL190742 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL425902 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL189223 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL191376 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL365963 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL424815 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL191204 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL190597 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL370889 | — | IC50 | = | 583.0 | nM | 6.23 |
| CHEMBL190250 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL364940 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL191465 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL191021 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL370899 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL191269 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL370477 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL363155 | — | IC50 | = | 993.0 | nM | 6.00 |
| CHEMBL425553 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL370960 | — | IC50 | = | 1324.0 | nM | 5.88 |
| CHEMBL191543 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL363556 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL190859 | — | IC50 | = | 1644.0 | nM | 5.78 |
| CHEMBL189421 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL188499 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL370516 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL373086 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL365191 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL364053 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL362934 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL365146 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL191536 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL190457 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL190380 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL189931 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL189993 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL190363 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL362926 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL372933 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL191498 | — | IC50 | > | 5000.0 | nM | - |