Assay Detail
Binding
CHEMBL829696
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Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-4 receptor expressed in HEK293 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a beta-MSH-derived MC-4R selective agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.91 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415661 | — | — | 1 | 9.85 |
| CHEMBL414718 | — | — | 1 | 9.57 |
| CHEMBL407809 | — | — | 1 | 9.55 |
| CHEMBL412523 | — | — | 1 | 9.52 |
| CHEMBL415165 | — | — | 1 | 9.51 |
| CHEMBL408257 | — | — | 1 | 9.36 |
| CHEMBL2373515 | — | — | 1 | 9.28 |
| CHEMBL267900 | — | — | 1 | 9.26 |
| CHEMBL266879 | — | — | 1 | 9.26 |
| CHEMBL264352 | — | — | 1 | 9.11 |
| CHEMBL412495 | — | — | 1 | 8.91 |
| CHEMBL385556 | — | — | 1 | 8.64 |
| CHEMBL412494 | — | — | 1 | 8.60 |
| CHEMBL428326 | — | — | 1 | 8.28 |
| CHEMBL264132 | — | — | 1 | 8.18 |
| CHEMBL412536 | — | — | 1 | 8.09 |
| CHEMBL427666 | — | — | 1 | 7.88 |
| CHEMBL410672 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415661 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL414718 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL407809 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL412523 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL415165 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL408257 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL2373515 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL267900 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL266879 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL264352 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL412495 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL385556 | — | Ki | = | 2.29 | nM | 8.64 |
| CHEMBL412494 | — | Ki | = | 2.54 | nM | 8.60 |
| CHEMBL428326 | — | Ki | = | 5.28 | nM | 8.28 |
| CHEMBL264132 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL412536 | — | Ki | = | 8.18 | nM | 8.09 |
| CHEMBL427666 | — | Ki | = | 13.25 | nM | 7.88 |
| CHEMBL410672 | — | Ki | = | 30.51 | nM | 7.52 |