Compound Detail
CHEMBL264132
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]1CSSC[C@H](C(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cncn2C)NC(=O)[C@@H](CCC(=O)O)NC1=O
Basic Information
| ChEMBL ID | CHEMBL264132 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | JCRBBWBYSVHLIT-PYPSSTHSSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
1352.6
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.27
Ki 1 meas. best 8.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 4 CHEMBL259 | EC50 | 9.27 | 9.27 | 0.5 | 1 |
| Melanocortin receptor 4 CHEMBL259 | Ki | 8.18 | 8.18 | 6.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 4 | EC50 | = | 0.54 | nM | 9.27 | Agonist activity at human Melanocortin-4 receptor as peptide required for 50% ma... | 15857110 |
| Melanocortin receptor 4 | Ki | = | 6.6 | nM | 8.18 | Inhibition of [125I]NDP-alpha-MSH binding to melanocortin-4 receptor expressed i... | 15857110 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15857110 | 10.1021/jm0501432 | Melanocortin receptor 4 | 3 |
| 15857110 | 10.1021/jm0501432 | Melanocyte-stimulating hormone receptor | 1 |
| 15857110 | 10.1021/jm0501432 | Melanocortin receptor 3 | 1 |
| 15857110 | 10.1021/jm0501432 | Melanocortin receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine