Assay Detail
Functional
CHEMBL832471
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Agonist activity at human Melanocortin-4 receptor as peptide required for 50% maximal cAMP release (n > or =2)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a beta-MSH-derived MC-4R selective agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 9.39 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415661 | — | — | 1 | 10.22 |
| CHEMBL412495 | — | — | 1 | 10.00 |
| CHEMBL407809 | — | — | 1 | 9.92 |
| CHEMBL266879 | — | — | 1 | 9.80 |
| CHEMBL2373515 | — | — | 1 | 9.62 |
| CHEMBL408257 | — | — | 1 | 9.59 |
| CHEMBL264352 | — | — | 1 | 9.57 |
| CHEMBL267900 | — | — | 1 | 9.55 |
| CHEMBL385556 | — | — | 1 | 9.52 |
| CHEMBL415165 | — | — | 1 | 9.44 |
| CHEMBL264132 | — | — | 1 | 9.27 |
| CHEMBL414718 | — | — | 1 | 9.25 |
| CHEMBL412523 | — | — | 1 | 9.19 |
| CHEMBL428326 | — | — | 1 | 9.17 |
| CHEMBL412494 | — | — | 1 | 9.10 |
| CHEMBL427666 | — | — | 1 | 9.04 |
| CHEMBL412536 | — | — | 1 | 8.49 |
| CHEMBL410672 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415661 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL412495 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL407809 | — | EC50 | = | 0.12 | nM | 9.92 |
| CHEMBL266879 | — | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2373515 | — | EC50 | = | 0.24 | nM | 9.62 |
| CHEMBL408257 | — | EC50 | = | 0.26 | nM | 9.59 |
| CHEMBL264352 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL267900 | — | EC50 | = | 0.28 | nM | 9.55 |
| CHEMBL385556 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL415165 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL264132 | — | EC50 | = | 0.54 | nM | 9.27 |
| CHEMBL414718 | — | EC50 | = | 0.56 | nM | 9.25 |
| CHEMBL412523 | — | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL428326 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL412494 | — | EC50 | = | 0.79 | nM | 9.10 |
| CHEMBL427666 | — | EC50 | = | 0.92 | nM | 9.04 |
| CHEMBL412536 | — | EC50 | = | 3.24 | nM | 8.49 |
| CHEMBL410672 | — | EC50 | = | 5.24 | nM | 8.28 |