Assay Detail
Functional
CHEMBL829972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain Serotonin transporter as accumulation of [3H]5-HT
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.15 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113053 | — | — | 1 | 7.71 |
| CHEMBL2113050 | — | — | 1 | 7.68 |
| CHEMBL211484 | — | — | 1 | 7.59 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.04 |
| CHEMBL2112061 | — | — | 1 | 6.22 |
| CHEMBL2112056 | — | — | 1 | 6.17 |
| CHEMBL2113048 | — | — | 1 | 6.15 |
| CHEMBL2113052 | — | — | 1 | 6.10 |
| CHEMBL2112057 | — | — | 1 | 5.58 |
| CHEMBL2113044 | — | — | 1 | 5.49 |
| CHEMBL2112059 | — | — | 1 | 5.47 |
| CHEMBL2112060 | — | — | 1 | 5.40 |
| CHEMBL2113047 | — | — | 1 | 5.30 |
| CHEMBL2112058 | — | — | 1 | 5.26 |
| CHEMBL2113049 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113053 | — | Ki | = | 19.7 | nM | 7.71 |
| CHEMBL2113050 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL211484 | — | Ki | = | 25.9 | nM | 7.59 |
| CHEMBL281594 | VANOXERINE | Ki | = | 91.1 | nM | 7.04 |
| CHEMBL2112061 | — | Ki | = | 607.0 | nM | 6.22 |
| CHEMBL2112056 | — | Ki | = | 669.0 | nM | 6.17 |
| CHEMBL2113048 | — | Ki | = | 707.0 | nM | 6.15 |
| CHEMBL2113052 | — | Ki | = | 793.0 | nM | 6.10 |
| CHEMBL2112057 | — | Ki | = | 2650.0 | nM | 5.58 |
| CHEMBL2113044 | — | Ki | = | 3210.0 | nM | 5.49 |
| CHEMBL2112059 | — | Ki | = | 3420.0 | nM | 5.47 |
| CHEMBL2112060 | — | Ki | = | 3970.0 | nM | 5.40 |
| CHEMBL2113047 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL2112058 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL2113049 | — | Ki | = | 9560.0 | nM | 5.02 |