Assay Detail
Binding
CHEMBL830133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]citalopram binding to human serotonin transporter expressed in human HEK293 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.54 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23034 | — | — | 1 | 10.89 |
| CHEMBL22183 | — | — | 1 | 9.60 |
| CHEMBL189367 | — | — | 1 | 9.31 |
| CHEMBL190937 | — | — | 1 | 9.24 |
| CHEMBL190703 | — | — | 1 | 8.95 |
| CHEMBL190700 | — | — | 1 | 8.80 |
| CHEMBL2113054 | — | — | 1 | 8.71 |
| CHEMBL189375 | — | — | 1 | 8.69 |
| CHEMBL188964 | — | — | 1 | 8.07 |
| CHEMBL363396 | — | — | 1 | 8.07 |
| CHEMBL362783 | — | — | 1 | 7.82 |
| CHEMBL187935 | — | — | 1 | 7.30 |
| CHEMBL2113055 | — | — | 1 | 7.08 |
| CHEMBL413562 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23034 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL22183 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL189367 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL190937 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL190703 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL190700 | — | Ki | = | 1.59 | nM | 8.80 |
| CHEMBL2113054 | — | Ki | = | 1.94 | nM | 8.71 |
| CHEMBL189375 | — | Ki | = | 2.04 | nM | 8.69 |
| CHEMBL188964 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL363396 | — | Ki | = | 8.55 | nM | 8.07 |
| CHEMBL362783 | — | Ki | = | 15.11 | nM | 7.82 |
| CHEMBL187935 | — | Ki | = | 50.58 | nM | 7.30 |
| CHEMBL2113055 | — | Ki | = | 83.43 | nM | 7.08 |
| CHEMBL413562 | — | Ki | = | 92.26 | nM | 7.04 |