Assay Detail
ADMET
CHEMBL830895
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against cytochrome P450 determined using human liver microsome upon 15 min incubation with probes substrates Tolbutamide (2C9)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of bivalent ligands using hydrogen bond linkers: synthesis and evaluation of inhibitors for human beta-tryptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.80 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186730 | — | — | 1 | 6.32 |
| CHEMBL365062 | — | — | 1 | 5.27 |
| CHEMBL188068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186730 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL365062 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL188068 | — | IC50 | > | 50000.0 | nM | - |