Assay Detail
ADMET
CHEMBL830925
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Selectivity towards cytochrome P450 3A4 enzyme activity
30
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.48 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180348 | — | — | 1 | 8.40 |
| CHEMBL179825 | — | — | 1 | 8.40 |
| CHEMBL178474 | — | — | 2 | 8.00 |
| CHEMBL181385 | — | — | 2 | 7.40 |
| CHEMBL362412 | — | — | 2 | 6.85 |
| CHEMBL181309 | — | — | 2 | 6.80 |
| CHEMBL180856 | — | — | 1 | 6.70 |
| CHEMBL180805 | — | — | 2 | 6.66 |
| CHEMBL359627 | — | — | 2 | 6.58 |
| CHEMBL180592 | — | — | 1 | 6.46 |
| CHEMBL360072 | — | — | 1 | 6.45 |
| CHEMBL182438 | — | — | 1 | 6.40 |
| CHEMBL360148 | — | — | 1 | 6.32 |
| CHEMBL368448 | — | — | 2 | 6.19 |
| CHEMBL179550 | — | — | 1 | 6.12 |
| CHEMBL360771 | — | — | 2 | 5.83 |
| CHEMBL426789 | — | — | 2 | 5.80 |
| CHEMBL362489 | — | — | 1 | 5.74 |
| CHEMBL180829 | — | — | 1 | 5.70 |
| CHEMBL367357 | — | — | 1 | 5.69 |
| CHEMBL178873 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180348 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL179825 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL178474 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL181385 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL178474 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL362412 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL181309 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL180856 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL181309 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL362412 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL180805 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL359627 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL359627 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL180592 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL360072 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL182438 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL360148 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL181385 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL368448 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL180805 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL179550 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL368448 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL360771 | — | IC50 | = | 1488.0 | nM | 5.83 |
| CHEMBL426789 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL362489 | — | IC50 | = | 1835.0 | nM | 5.74 |
| CHEMBL180829 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL367357 | — | IC50 | = | 2032.0 | nM | 5.69 |
| CHEMBL178873 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL426789 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL360771 | — | IC50 | = | 6300.0 | nM | 5.20 |