Assay Detail
Binding
CHEMBL831374
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Inhibition of [3H]dexamethasone binding to rat glucocorticoid receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.93 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191423 | — | — | 1 | 9.70 |
| CHEMBL185265 | — | — | 1 | 9.00 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 8.85 |
| CHEMBL190109 | — | — | 1 | 8.72 |
| CHEMBL190225 | — | — | 1 | 8.68 |
| CHEMBL363151 | — | — | 1 | 8.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191423 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL185265 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL190109 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL190225 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL363151 | — | IC50 | = | 2.4 | nM | 8.62 |