Assay Detail
Binding
CHEMBL832761
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Inhibition of EGF Receptor autophosphorylation in A431 cell lysate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.18 | 10.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363815 | — | — | 1 | 10.43 |
| CHEMBL275762 | — | — | 1 | 10.15 |
| CHEMBL190094 | — | — | 1 | 9.96 |
| CHEMBL193160 | — | — | 1 | 9.92 |
| CHEMBL437879 | — | — | 1 | 9.68 |
| CHEMBL94061 | — | — | 1 | 9.39 |
| CHEMBL189779 | — | — | 1 | 9.03 |
| CHEMBL193159 | — | — | 1 | 7.50 |
| CHEMBL190567 | — | — | 1 | 6.82 |
| CHEMBL192737 | — | — | 1 | 6.76 |
| CHEMBL190651 | — | — | 1 | 6.60 |
| CHEMBL372246 | — | — | 1 | 5.22 |
| CHEMBL365805 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363815 | — | IC50 | = | 0.037 | nM | 10.43 |
| CHEMBL275762 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL190094 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL193160 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL437879 | — | IC50 | = | 0.208 | nM | 9.68 |
| CHEMBL94061 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL189779 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL193159 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL190567 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL192737 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL190651 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL372246 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL365805 | — | IC50 | = | 13000.0 | nM | 4.89 |