Compound Detail
CHEMBL192737
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Basic Information
| ChEMBL ID | CHEMBL192737 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HCGUXPNJBCSZTA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
387.2
MW (Da)
3.72
ALogP
5
HBA
2
HBD
76.1
PSA (Ų)
0.70
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 6.76 | 6.76 | 174.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 174.0 | nM | 6.76 | Inhibition of EGF Receptor autophosphorylation in A431 cell lysate | 16078851 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16078851 | 10.1021/jm0580196 | Epidermal growth factor receptor | 3 |
Data from ChEMBL 36 via Core Engine