Assay Detail
Binding
CHEMBL833025
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Inhibition of EGF Receptor autophosphorylation in A431 cell lysate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.61 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193159 | — | — | 1 | 8.00 |
| CHEMBL193160 | — | — | 1 | 7.52 |
| CHEMBL190567 | — | — | 1 | 4.30 |
| CHEMBL192737 | — | — | 1 | - |
| CHEMBL189779 | — | — | 1 | - |
| CHEMBL372246 | — | — | 1 | - |
| CHEMBL365805 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193159 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL193160 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL190567 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL192737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL189779 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL372246 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL365805 | — | IC50 | > | 500.0 | nM | - |