Assay Detail
Functional
CHEMBL833084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cellular reversion in H-ras transformed Rat-1 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Rat-1 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein farnesyltransferase (CHEMBL2095197) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.43 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183773 | — | — | 1 | 8.10 |
| CHEMBL179598 | — | — | 1 | 8.00 |
| CHEMBL360330 | — | — | 1 | 7.89 |
| CHEMBL183536 | — | — | 1 | 7.52 |
| CHEMBL181102 | — | — | 1 | 7.30 |
| CHEMBL182813 | — | — | 1 | 7.22 |
| CHEMBL439846 | — | — | 1 | 7.16 |
| CHEMBL183217 | — | — | 1 | 7.00 |
| CHEMBL183590 | — | — | 1 | 6.65 |
| CHEMBL180411 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183773 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL179598 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL360330 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL183536 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL181102 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL182813 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL439846 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL183217 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL183590 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL180411 | — | IC50 | < | 20.0 | nM | - |