Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL182813

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
C=C(C)CN(C1Cc2cc(C#N)ccc2N(Cc2cncn2C)C1)S(=O)(=O)c1ccccn1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL182813
Phase Preclinical
Structure Type MOL
InChI Key PZCCBYWNHZAHAG-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

462.6
MW (Da)
2.89
ALogP
7
HBA
0
HBD
95.1
PSA (Ų)
0.50
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H26N6O2S
MW 462.58
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -1.37

Activity Summary

IC50 2 meas. best 9.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Protein farnesyltransferase
CHEMBL2094108
 IC50 9.05 9.05 0.9 1
Protein farnesyltransferase
CHEMBL2095197
 IC50 7.22 7.22 60.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Protein farnesyltransferase IC50 = 0.9 nM 9.05 Inhibition of human farnesyltransferase 15780629
Protein farnesyltransferase IC50 = 60.0 nM 7.22 Inhibition of cellular reversion in H-ras transformed Rat-1 cells 15780629

Literature References

PubMed DOI Target Context # Activities
15780629 10.1016/j.bmcl.2005.02.004 Protein farnesyltransferase 3

Data from ChEMBL 36 via Core Engine