Assay Detail
Functional
CHEMBL833096
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Effective concentration required to inhibit herpes simplex virus 1 in BSC-1 cells in ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | herpes simplex virus |
| Cell Type | BSC-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 4.65 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.82 |
| CHEMBL372938 | — | — | 1 | 4.70 |
| CHEMBL157102 | — | — | 1 | 4.30 |
| CHEMBL427352 | — | — | 1 | 4.26 |
| CHEMBL192395 | — | — | 1 | 4.16 |
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | - |
| CHEMBL195174 | — | — | 1 | - |
| CHEMBL362940 | — | — | 1 | - |
| CHEMBL192301 | — | — | 1 | - |
| CHEMBL364236 | — | — | 1 | - |
| CHEMBL195171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL372938 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL157102 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL427352 | — | EC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL192395 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL265948 | FILOCICLOVIR | EC50 | > | 100000.0 | nM | - |
| CHEMBL195174 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL362940 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL192301 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL364236 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL195171 | — | EC50 | > | 100000.0 | nM | - |