Assay Detail
Functional
CHEMBL833209
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Inhibitory concentration in dilute prothrombin time assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.30 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440755 | — | — | 1 | 6.72 |
| CHEMBL182763 | — | — | 1 | 6.64 |
| CHEMBL185556 | — | — | 1 | 6.43 |
| CHEMBL183426 | — | — | 1 | 6.43 |
| CHEMBL182746 | — | — | 1 | 6.38 |
| CHEMBL366134 | — | — | 1 | 6.21 |
| CHEMBL182975 | — | — | 1 | 5.81 |
| CHEMBL180695 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440755 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL182763 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL185556 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL183426 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL182746 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL366134 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL182975 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL180695 | — | IC50 | = | 1790.0 | nM | 5.75 |