Compound Detail
CHEMBL182763
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL182763 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VGXIAQUUVIGDPS-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
518.0
MW (Da)
5.85
ALogP
7
HBA
1
HBD
76.2
PSA (Ų)
0.31
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.64
Ki 1 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Coagulation factor X CHEMBL244 | Ki | 7.85 | 7.85 | 14.0 | 1 |
| Prothrombin CHEMBL204 | IC50 | 6.64 | 6.64 | 230.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Coagulation factor X | Ki | = | 14.0 | nM | 7.85 | Inhibitory activity against serine protease factor Xa | 15261269 |
| Prothrombin | IC50 | = | 230.0 | nM | 6.64 | Inhibitory concentration in dilute prothrombin time assay | 15261269 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15261269 | 10.1016/j.bmcl.2004.06.019 | Prothrombin | 3 |
| 15261269 | 10.1016/j.bmcl.2004.06.019 | Coagulation factor X | 1 |
| 15261269 | 10.1016/j.bmcl.2004.06.019 | Trypsin | 1 |
| 15261269 | 10.1016/j.bmcl.2004.06.019 | Kallikrein-1 | 1 |
| 15261269 | 10.1016/j.bmcl.2004.06.019 | Tissue-type plasminogen activator | 1 |
| 15261269 | 10.1016/j.bmcl.2004.06.019 | Tissue factor | 1 |
Data from ChEMBL 36 via Core Engine