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Assay Detail

CHEMBL833259

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Functional
inhibitory concentration against auto-oxidative lipid peroxidation in canine brain homogenate
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Canis lupus familiaris
Tissue Brain
Confidence 1 — Organism
Curated By Intermediate

Target

Oryctolagus cuniculus (CHEMBL374)
Type ORGANISM
Organism Oryctolagus cuniculus

Publication

Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter.
Kimura M, Masuda T, Yamada K, Kawakatsu N, Kubota N, Mitani M, Kishii K, Inazu M, Kiuchi Y, Oguchi K, Namiki T.
Bioorg Med Chem Lett (2004) 14 : 4287 -4290
PubMed 15261288 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.40 6.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1794970 1 6.50
CHEMBL1794972 1 5.85
CHEMBL47 ALPHA-TOCOPHEROL 1 5.82
CHEMBL539328 1 5.80
CHEMBL1794968 1 5.66
CHEMBL1794969 1 5.57
CHEMBL1794971 1 5.55
CHEMBL558574 1 5.21
CHEMBL536040 1 5.19
CHEMBL536547 1 5.16
CHEMBL536491 1 5.08
CHEMBL1794973 1 5.07
CHEMBL557197 1 4.96
CHEMBL538317 1 4.96
CHEMBL3217093 1 4.64
CHEMBL536489 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1794970 IC50 = 320.0 nM 6.50
CHEMBL1794972 IC50 = 1400.0 nM 5.85
CHEMBL47 ALPHA-TOCOPHEROL IC50 = 1500.0 nM 5.82
CHEMBL539328 IC50 = 1600.0 nM 5.80
CHEMBL1794968 IC50 = 2200.0 nM 5.66
CHEMBL1794969 IC50 = 2700.0 nM 5.57
CHEMBL1794971 IC50 = 2800.0 nM 5.55
CHEMBL558574 IC50 = 6100.0 nM 5.21
CHEMBL536040 IC50 = 6500.0 nM 5.19
CHEMBL536547 IC50 = 6900.0 nM 5.16
CHEMBL536491 IC50 = 8300.0 nM 5.08
CHEMBL1794973 IC50 = 8500.0 nM 5.07
CHEMBL557197 IC50 = 11000.0 nM 4.96
CHEMBL538317 IC50 = 11000.0 nM 4.96
CHEMBL3217093 IC50 = 23000.0 nM 4.64
CHEMBL536489 IC50 = 182000.0 nM -