Assay Detail
Functional
CHEMBL833276
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Serotonin 5-HT2A receptor-mediated intracellular calcium [Ca2+] mobilization in rat A7r5 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | A7R5 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.50 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69700 | — | — | 1 | 7.70 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 7.22 |
| CHEMBL188709 | — | — | 1 | 7.00 |
| CHEMBL191051 | — | — | 1 | 6.92 |
| CHEMBL365958 | — | — | 1 | 6.89 |
| CHEMBL6737 | — | — | 1 | 6.13 |
| CHEMBL191286 | — | — | 1 | 6.08 |
| CHEMBL364718 | — | — | 1 | 5.88 |
| CHEMBL191420 | — | — | 1 | 5.85 |
| CHEMBL363772 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69700 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL6607 | BROLAMFETAMINE | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL188709 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL191051 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL365958 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL6737 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL191286 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL364718 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL191420 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL363772 | — | EC50 | = | 5040.0 | nM | 5.30 |