Assay Detail
Functional
CHEMBL833392
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Inhibitory concentration towards human ovarian carcinoma cell line A2780
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.65 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365341 | — | — | 1 | 6.66 |
| CHEMBL115220 | — | — | 1 | 6.54 |
| CHEMBL190206 | — | — | 1 | 6.43 |
| CHEMBL195683 | — | — | 1 | 6.20 |
| CHEMBL191144 | — | — | 1 | 6.10 |
| CHEMBL191834 | — | — | 1 | 6.10 |
| CHEMBL190446 | — | — | 1 | 5.99 |
| CHEMBL192339 | — | — | 1 | 5.98 |
| CHEMBL192602 | — | — | 1 | 5.90 |
| CHEMBL192042 | — | — | 1 | 5.85 |
| CHEMBL359556 | — | — | 1 | 5.78 |
| CHEMBL192716 | — | — | 1 | 5.65 |
| CHEMBL193288 | — | — | 1 | 5.34 |
| CHEMBL366032 | — | — | 1 | 5.32 |
| CHEMBL370724 | — | — | 1 | 5.28 |
| CHEMBL192556 | — | — | 1 | 5.24 |
| CHEMBL193673 | — | — | 1 | 5.19 |
| CHEMBL193210 | — | — | 1 | 5.16 |
| CHEMBL370817 | — | — | 1 | 5.08 |
| CHEMBL192471 | — | — | 1 | 4.91 |
| CHEMBL189047 | — | — | 1 | 4.88 |
| CHEMBL192440 | — | — | 1 | 4.82 |
| CHEMBL373346 | — | — | 1 | - |
| CHEMBL372467 | — | — | 1 | - |
| CHEMBL191865 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365341 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL115220 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL190206 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL195683 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL191144 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL191834 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL190446 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL192339 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL192602 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL192042 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL359556 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL192716 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL193288 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL366032 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL370724 | — | IC50 | = | 5240.0 | nM | 5.28 |
| CHEMBL192556 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL193673 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL193210 | — | IC50 | = | 6980.0 | nM | 5.16 |
| CHEMBL370817 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL192471 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL189047 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL192440 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL373346 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL372467 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL191865 | — | IC50 | > | 10000.0 | nM | - |