Assay Detail
Functional
CHEMBL833433
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Cytotoxic concentration against murine P388 leukemia cell line growth determined by microculture tetrazolium-formazan method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.42 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365563 | — | — | 1 | 7.51 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 6.70 |
| CHEMBL191590 | — | — | 1 | 6.19 |
| CHEMBL371556 | — | — | 1 | 5.95 |
| CHEMBL193026 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365563 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL191590 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL371556 | — | IC50 | = | 1127.0 | nM | 5.95 |
| CHEMBL193026 | — | IC50 | = | 1703.0 | nM | 5.77 |