Assay Detail
Functional
CHEMBL833436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of androgen dependent human prostate cancer cell MDA-MB-PCa2b proliferation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cancer cell lines |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.82 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182412 | — | — | 1 | 9.40 |
| CHEMBL182993 | — | — | 1 | 6.83 |
| CHEMBL182593 | — | — | 1 | 6.75 |
| CHEMBL183882 | — | — | 1 | 6.75 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | 6.14 |
| CHEMBL183173 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182412 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL182993 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL182593 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL183882 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL183173 | — | IC50 | = | 8460.0 | nM | 5.07 |