Compound Detail
CHEMBL182412
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL182412 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QCKPIKBKCZBMEY-SUBVLCJKSA-N |
1
Targets
5
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
321.3
MW (Da)
3.41
ALogP
2
HBA
0
HBD
37.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.4
Ki 2 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Androgen receptor CHEMBL1871 | IC50 | 9.4 | 7.7633 | 0.4 | 3 |
| Androgen receptor CHEMBL1871 | Ki | 7.72 | 7.36 | 19.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Androgen receptor | IC50 | = | 0.4 | nM | 9.4 | Inhibition of androgen dependent human prostate cancer cell MDA-MB-PCa2b prolife... | 15603938 |
| Androgen receptor | Ki | = | 19.0 | nM | 7.72 | Binding affinity for mutant T877A Androgen receptor in human LNCaP cells | 15603938 |
| Androgen receptor | IC50 | = | 66.0 | nM | 7.18 | Inhibition of mutant T877A Androgen receptor in human LNCaP cells | 15603938 |
| Androgen receptor | Ki | = | 100.0 | nM | 7.0 | Binding affinity for androgen receptor in human MDA-453 cells | 15603938 |
| Androgen receptor | IC50 | = | 196.0 | nM | 6.71 | Inhibition of androgen receptor in human MDA-453 cells | 15603938 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15603938 | 10.1016/j.bmcl.2004.10.085 | Androgen receptor | 5 |
Data from ChEMBL 36 via Core Engine