Assay Detail
Binding
CHEMBL833492
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Binding affinity towards hippocampus 5-hydroxytryptamine 1 receptor was measured using radioligand [3H]5-HT
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 1 (5-HT1) receptor (CHEMBL2095159) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.60 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200399 | BUSPIRONE HYDROCHLORIDE | 4.0 | 1 | 7.02 |
| CHEMBL1204187 | GEPIRONE HYDROCHLORIDE | 4.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200399 | BUSPIRONE HYDROCHLORIDE | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1204187 | GEPIRONE HYDROCHLORIDE | IC50 | = | 670.0 | nM | 6.17 |