Assay Detail
Functional
CHEMBL833647
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for serotonin transporter
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.47 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92860 | — | — | 1 | 8.77 |
| CHEMBL91157 | — | — | 1 | 8.64 |
| CHEMBL419316 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92860 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL91157 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL419316 | — | Ki | = | 10.0 | nM | 8.00 |