Assay Detail
Functional
CHEMBL833808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of compound required for inhibition of (IGROV-1) human ovarian carcinoma cell growth by 50%
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.51 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443225 | — | — | 1 | 6.70 |
| CHEMBL442016 | ADAROTENE | — | 1 | 6.64 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | — | 2 | 6.46 |
| CHEMBL191485 | — | — | 1 | 6.43 |
| CHEMBL176252 | — | — | 1 | 6.24 |
| CHEMBL187397 | — | — | 1 | 6.21 |
| CHEMBL188165 | — | — | 1 | 5.94 |
| CHEMBL365867 | — | — | 1 | 5.94 |
| CHEMBL191559 | — | — | 1 | 5.89 |
| CHEMBL372221 | — | — | 1 | 5.88 |
| CHEMBL188026 | — | — | 1 | 5.68 |
| CHEMBL187445 | — | — | 1 | 5.66 |
| CHEMBL188331 | — | — | 1 | 5.59 |
| CHEMBL188498 | — | — | 1 | 5.45 |
| CHEMBL427521 | — | — | 1 | 5.21 |
| CHEMBL188699 | — | — | 1 | 5.18 |
| CHEMBL187730 | — | — | 1 | 5.14 |
| CHEMBL425361 | — | — | 1 | 5.08 |
| CHEMBL364151 | — | — | 1 | 5.00 |
| CHEMBL191233 | — | — | 1 | 4.97 |
| CHEMBL189565 | — | — | 1 | 4.72 |
| CHEMBL190337 | — | — | 1 | 4.71 |
| CHEMBL190792 | — | — | 1 | 4.58 |
| CHEMBL187989 | — | — | 1 | 4.52 |
| CHEMBL541981 | — | — | 1 | 4.32 |
| CHEMBL187836 | — | — | 1 | 4.05 |
| CHEMBL187661 | — | — | 1 | - |
| CHEMBL361692 | — | — | 1 | - |
| CHEMBL365938 | — | — | 1 | - |
| CHEMBL188594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443225 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL442016 | ADAROTENE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL191485 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL176252 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL187397 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL188165 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL365867 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL191559 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL372221 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL188026 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL187445 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL188331 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL188498 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL427521 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL188699 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL187730 | — | IC50 | = | 7190.0 | nM | 5.14 |
| CHEMBL425361 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL364151 | — | IC50 | = | 9970.0 | nM | 5.00 |
| CHEMBL191233 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL189565 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL190337 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL190792 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL187989 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL541981 | — | IC50 | = | 48420.0 | nM | 4.32 |
| CHEMBL187836 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL187661 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL361692 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL365938 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL188594 | — | IC50 | > | 3000.0 | nM | - |