Assay Detail
Functional
CHEMBL833828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of isolated guinea pig ileum contraction induced by electrical stimulation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Morphiceptin analogues containing a dipeptide mimetic structure: an investigation on the bioactive topology at the mu-receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.36 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113058 | — | — | 1 | 8.01 |
| CHEMBL267708 | — | — | 1 | 7.89 |
| CHEMBL2113060 | — | — | 1 | 7.55 |
| CHEMBL2113059 | — | — | 1 | 7.44 |
| CHEMBL38874 | DAMGO | — | 1 | 7.44 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.89 |
| CHEMBL841 | LOPERAMIDE | 4.0 | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113058 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL267708 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2113060 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2113059 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL38874 | DAMGO | EC50 | = | 36.2 | nM | 7.44 |
| CHEMBL70 | MORPHINE | EC50 | = | 127.4 | nM | 6.89 |
| CHEMBL841 | LOPERAMIDE | EC50 | = | 488.9 | nM | 6.31 |