Assay Detail
Functional
CHEMBL833946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of A2780 ovarian tumor cell proliferation
59
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Benzodipyrazoles: a new class of potent CDK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 5.50 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182209 | — | — | 1 | 6.58 |
| CHEMBL554716 | — | — | 1 | 6.40 |
| CHEMBL180715 | — | — | 1 | 6.24 |
| CHEMBL178190 | — | — | 1 | 6.19 |
| CHEMBL367798 | — | — | 1 | 6.06 |
| CHEMBL369522 | — | — | 1 | 6.04 |
| CHEMBL181616 | — | — | 1 | 5.90 |
| CHEMBL181036 | — | — | 1 | 5.90 |
| CHEMBL178629 | — | — | 1 | 5.84 |
| CHEMBL368043 | — | — | 1 | 5.82 |
| CHEMBL362829 | — | — | 1 | 5.78 |
| CHEMBL178452 | — | — | 1 | 5.78 |
| CHEMBL178478 | — | — | 1 | 5.75 |
| CHEMBL178505 | — | — | 1 | 5.73 |
| CHEMBL178750 | — | — | 1 | 5.72 |
| CHEMBL179588 | — | — | 1 | 5.71 |
| CHEMBL181223 | — | — | 1 | 5.68 |
| CHEMBL362656 | — | — | 1 | 5.60 |
| CHEMBL181790 | — | — | 1 | 5.57 |
| CHEMBL178827 | — | — | 1 | 5.56 |
| CHEMBL359461 | — | — | 1 | 5.55 |
| CHEMBL178544 | — | — | 1 | 5.54 |
| CHEMBL360986 | — | — | 2 | 5.53 |
| CHEMBL362004 | — | — | 1 | 5.45 |
| CHEMBL178535 | — | — | 1 | 5.39 |
| CHEMBL360480 | — | — | 1 | 5.39 |
| CHEMBL440379 | — | — | 1 | 5.39 |
| CHEMBL367363 | — | — | 1 | 5.35 |
| CHEMBL180916 | — | — | 1 | 5.35 |
| CHEMBL179112 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182209 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL554716 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL180715 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL178190 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL367798 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL369522 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL181616 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL181036 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL178629 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL368043 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL362829 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL178452 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL178478 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL178505 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL178750 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL179588 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL181223 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL362656 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL181790 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL178827 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL359461 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL178544 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL360986 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL362004 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL360986 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL178535 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL440379 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL360480 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL367363 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL180916 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL179112 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL181462 | — | IC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL181828 | — | IC50 | = | 6050.0 | nM | 5.22 |
| CHEMBL179758 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL179548 | — | IC50 | = | 8050.0 | nM | 5.09 |
| CHEMBL178183 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL359738 | — | IC50 | = | 8750.0 | nM | 5.06 |
| CHEMBL360520 | — | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL360312 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL361595 | — | IC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL360149 | — | IC50 | = | 9760.0 | nM | 5.01 |
| CHEMBL178107 | — | IC50 | = | 9760.0 | nM | 5.01 |
| CHEMBL179710 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL182256 | — | IC50 | = | 13450.0 | nM | 4.87 |
| CHEMBL178965 | — | IC50 | = | 13920.0 | nM | 4.86 |
| CHEMBL178717 | — | IC50 | = | 18190.0 | nM | 4.74 |
| CHEMBL179385 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL179511 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL359737 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL426059 | — | IC50 | > | 20000.0 | nM | - |