Assay Detail
Functional
CHEMBL833969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of compound required for inhibition of (NB4) human promyelocytic leukemia cell growth by 50%
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NB-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.51 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191485 | — | — | 1 | 7.09 |
| CHEMBL442016 | ADAROTENE | — | 1 | 7.09 |
| CHEMBL443225 | — | — | 1 | 6.77 |
| CHEMBL176252 | — | — | 1 | 6.70 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | — | 2 | 6.40 |
| CHEMBL191559 | — | — | 1 | 5.98 |
| CHEMBL188165 | — | — | 1 | 5.92 |
| CHEMBL372221 | — | — | 1 | 5.92 |
| CHEMBL187445 | — | — | 1 | 5.82 |
| CHEMBL190337 | — | — | 1 | 5.77 |
| CHEMBL365867 | — | — | 1 | 5.77 |
| CHEMBL188026 | — | — | 1 | 5.75 |
| CHEMBL188699 | — | — | 1 | 5.70 |
| CHEMBL188331 | — | — | 1 | 5.66 |
| CHEMBL187730 | — | — | 1 | 5.64 |
| CHEMBL364151 | — | — | 1 | 5.17 |
| CHEMBL191233 | — | — | 1 | 5.04 |
| CHEMBL425361 | — | — | 1 | 4.84 |
| CHEMBL187397 | — | — | 1 | 4.74 |
| CHEMBL365938 | — | — | 1 | 4.65 |
| CHEMBL188594 | — | — | 1 | 4.45 |
| CHEMBL361692 | — | — | 1 | 4.41 |
| CHEMBL187989 | — | — | 1 | 4.37 |
| CHEMBL189565 | — | — | 1 | 4.34 |
| CHEMBL541981 | — | — | 1 | 4.20 |
| CHEMBL187836 | — | — | 1 | 4.10 |
| CHEMBL187661 | — | — | 1 | - |
| CHEMBL427521 | — | — | 1 | - |
| CHEMBL188498 | — | — | 1 | - |
| CHEMBL190792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191485 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL442016 | ADAROTENE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL443225 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL176252 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL191559 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL188165 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL372221 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL187445 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL190337 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL365867 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL188026 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL188699 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL188331 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL187730 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL364151 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL191233 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL425361 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL187397 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL365938 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL188594 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL361692 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL187989 | — | IC50 | = | 42300.0 | nM | 4.37 |
| CHEMBL189565 | — | IC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL541981 | — | IC50 | = | 63600.0 | nM | 4.20 |
| CHEMBL187836 | — | IC50 | = | 78700.0 | nM | 4.10 |
| CHEMBL187661 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL188498 | — | IC50 | - | nM | - | |
| CHEMBL427521 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL190792 | — | IC50 | - | nM | - |