Assay Detail
Functional
CHEMBL833970
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Concentration required for 50% growth inhibition of human HCT-15 cancer cell lines after 3 days of culture
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.61 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368047 | — | — | 1 | 7.80 |
| CHEMBL175452 | — | — | 1 | 7.68 |
| CHEMBL178993 | — | — | 1 | 7.62 |
| CHEMBL360322 | — | — | 1 | 7.57 |
| CHEMBL369587 | — | — | 1 | 7.57 |
| CHEMBL175806 | — | — | 1 | 7.55 |
| CHEMBL176316 | — | — | 1 | 7.51 |
| CHEMBL175946 | — | — | 1 | 7.47 |
| CHEMBL175947 | — | — | 1 | 7.36 |
| CHEMBL433564 | — | — | 1 | 7.31 |
| CHEMBL177836 | — | — | 1 | 7.04 |
| CHEMBL175716 | — | — | 1 | 6.42 |
| CHEMBL180496 | — | — | 1 | 6.36 |
| CHEMBL369515 | — | — | 1 | 6.34 |
| CHEMBL175719 | — | — | 1 | 5.82 |
| CHEMBL434923 | — | — | 1 | 5.57 |
| CHEMBL175769 | — | — | 1 | 5.49 |
| CHEMBL175921 | — | — | 1 | 5.44 |
| CHEMBL366906 | — | — | 1 | 5.44 |
| CHEMBL175981 | — | — | 1 | 5.38 |
| CHEMBL360496 | — | — | 1 | 5.35 |
| CHEMBL178933 | — | — | 1 | 5.24 |
| CHEMBL426228 | — | — | 1 | - |
| CHEMBL366970 | — | — | 1 | - |
| CHEMBL367694 | — | — | 1 | - |
| CHEMBL427124 | — | — | 1 | - |
| CHEMBL262795 | — | — | 1 | - |
| CHEMBL360685 | — | — | 1 | - |
| CHEMBL367124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368047 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL175452 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL178993 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL360322 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL369587 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL175806 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL176316 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL175946 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL175947 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL433564 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL177836 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL175716 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL180496 | — | IC50 | = | 442.0 | nM | 6.36 |
| CHEMBL369515 | — | IC50 | = | 454.0 | nM | 6.34 |
| CHEMBL175719 | — | IC50 | = | 1499.0 | nM | 5.82 |
| CHEMBL434923 | — | IC50 | = | 2686.0 | nM | 5.57 |
| CHEMBL175769 | — | IC50 | = | 3238.0 | nM | 5.49 |
| CHEMBL175921 | — | IC50 | = | 3621.0 | nM | 5.44 |
| CHEMBL366906 | — | IC50 | = | 3658.0 | nM | 5.44 |
| CHEMBL175981 | — | IC50 | = | 4126.0 | nM | 5.38 |
| CHEMBL360496 | — | IC50 | = | 4432.0 | nM | 5.35 |
| CHEMBL178933 | — | IC50 | = | 5797.0 | nM | 5.24 |
| CHEMBL426228 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL366970 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL367694 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL427124 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL262795 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL360685 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL367124 | — | IC50 | > | 10000.0 | nM | - |