Assay Detail
Functional
CHEMBL834018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against serotonin transporter protein (SERT) expressed in HEK293 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Homotryptamines as potent and selective serotonin reuptake inhibitors (SSRIs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.47 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179767 | — | — | 1 | 8.70 |
| CHEMBL180630 | — | — | 1 | 8.70 |
| CHEMBL361949 | — | — | 1 | 8.40 |
| CHEMBL362170 | — | — | 1 | 8.15 |
| CHEMBL183238 | — | — | 1 | 7.96 |
| CHEMBL183488 | — | — | 1 | 7.77 |
| CHEMBL2113005 | — | — | 1 | 7.75 |
| CHEMBL182386 | — | — | 1 | 7.54 |
| CHEMBL183542 | — | — | 1 | 7.51 |
| CHEMBL180537 | — | — | 1 | 7.50 |
| CHEMBL361622 | — | — | 1 | 7.44 |
| CHEMBL360575 | — | — | 1 | 7.24 |
| CHEMBL368229 | — | — | 1 | 5.96 |
| CHEMBL416526 | BUFOTENINE | — | 1 | 5.92 |
| CHEMBL2113003 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179767 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL180630 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL361949 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL362170 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL183238 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL183488 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2113005 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL182386 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL183542 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL180537 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL361622 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL360575 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL368229 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL416526 | BUFOTENINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2113003 | — | IC50 | = | 3200.0 | nM | 5.50 |