Assay Detail
Functional
CHEMBL834062
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against human immunodeficiency virus type 1 mutated at 227L+106A
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.94 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 9.00 |
| CHEMBL367969 | — | — | 1 | 8.50 |
| CHEMBL424781 | — | — | 1 | 8.40 |
| CHEMBL177437 | — | — | 1 | 8.40 |
| CHEMBL177643 | — | — | 1 | 8.40 |
| CHEMBL2096760 | — | — | 1 | 8.30 |
| CHEMBL443047 | — | — | 1 | 8.30 |
| CHEMBL177703 | — | — | 1 | 8.10 |
| CHEMBL70442 | — | — | 1 | 7.90 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.60 |
| CHEMBL175913 | — | — | 1 | 7.60 |
| CHEMBL368555 | — | — | 1 | 7.50 |
| CHEMBL360489 | — | — | 1 | 7.30 |
| CHEMBL369875 | — | — | 1 | 6.90 |
| CHEMBL369518 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL367969 | — | EC50 | = | 3.16 | nM | 8.50 |
| CHEMBL424781 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL177437 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL177643 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2096760 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL443047 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL177703 | — | EC50 | = | 7.95 | nM | 8.10 |
| CHEMBL70442 | — | EC50 | = | 12.6 | nM | 7.90 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 25.1 | nM | 7.60 |
| CHEMBL175913 | — | EC50 | = | 25.1 | nM | 7.60 |
| CHEMBL368555 | — | EC50 | = | 31.6 | nM | 7.50 |
| CHEMBL360489 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL369875 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL369518 | — | EC50 | = | 125.0 | nM | 6.90 |