Assay Detail
Functional
CHEMBL834069
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Effective concentration against thymidine kinase deficient herpes simplex virus (HSV-2) in VMW-1837 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Cell Type | VMW-1837 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.80 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372283 | CARBOVIR | — | 1 | 4.89 |
| CHEMBL192616 | — | — | 1 | 4.70 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | - |
| CHEMBL363136 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372283 | CARBOVIR | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL192616 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 320000.0 | nM | - |
| CHEMBL363136 | — | EC50 | = | 480000.0 | nM | - |