Assay Detail
Functional
CHEMBL834109
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Tested for inhibition of ferrous salt/ascorbate induced lipidic peroxidation of membrane lipid of rat hepatocytes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.91 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188200 | — | — | 1 | 6.82 |
| CHEMBL37676 | APC-100 | 1.0 | 1 | 6.77 |
| CHEMBL360593 | — | — | 1 | 6.31 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | 2.0 | 1 | 5.77 |
| CHEMBL187824 | — | — | 1 | 5.70 |
| CHEMBL187933 | — | — | 1 | 5.70 |
| CHEMBL189804 | — | — | 1 | 4.33 |
| CHEMBL363325 | — | — | 1 | - |
| CHEMBL188760 | — | — | 1 | - |
| CHEMBL16645 | p-CRESOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188200 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL37676 | APC-100 | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL360593 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL146 | BUTYLATED HYDROXYTOLUENE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL187824 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL187933 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL189804 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL363325 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL188760 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL16645 | p-CRESOL | IC50 | = | 290000.0 | nM | - |