Compound Detail
CHEMBL37676
APC-100 Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL37676 |
| Name | APC-100 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | SEBPXHSZHLFWRL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
11
Publications
4
Known Names
1
Indications
1
Mechanisms
Molecular Properties
220.3
MW (Da)
3.42
ALogP
2
HBA
1
HBD
29.5
PSA (Ų)
0.73
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Androgen Receptor antagonist | ANTAGONIST | Androgen receptor | ✓ | ✓ |
Indications
Prostatic Neoplasms, Castration-Resistant
Activity Summary
IC50 2 meas. best 6.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | IC50 | 6.77 | 6.77 | 170.0 | 1 |
| Radical scavenging activity CHEMBL613712 | IC50 | 6.77 | 6.77 | 170.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | IC50 | = | 170.0 | nM | 6.77 | Tested for inhibition of ferrous salt/ascorbate induced lipidic peroxidation of ... | 15546710 |
| Radical scavenging activity | IC50 | = | 170.0 | nM | 6.77 | Antioxidant activity assessed as inhibition of TBARS production in ferrous salt/... | 16686532 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2329571 | 10.1021/jm00167a032 | Rattus norvegicus | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 15546710 | 10.1016/j.bmcl.2004.10.006 | Rattus norvegicus | 1 |
| 16686532 | 10.1021/jm0510530 | Radical scavenging activity | 1 |
| 19232450 | 10.1016/j.ejmech.2009.01.017 | Mycobacterium tuberculosis | 1 |
| 19232450 | 10.1016/j.ejmech.2009.01.017 | Mycobacterium tuberculosis variant bovis BCG | 1 |
| 19232450 | 10.1016/j.ejmech.2009.01.017 | Vero | 1 |
| 19232450 | 10.1016/j.ejmech.2009.01.017 | Escherichia coli | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine