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Assay Detail

CHEMBL834236

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration required to reduce thymidine kinase-Varicella Zoster virus VZV 07/1 plaque formation by using DMSO as solvent
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Varicellaria
Confidence 3 — Cell-line / Tissue
Curated By Autocuration

Publication

Bicyclic nucleoside inhibitors of Varicella-Zoster virus: the effect of branching in the p-alkylphenyl side chain.
Luoni G, McGuigan C, Andrei G, Snoeck R, De Clercq E, Balzarini J.
Bioorg Med Chem Lett (2005) 15 : 3791 -3796
PubMed 15993062 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 4.27 4.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL184 ACYCLOVIR 4.0 1 4.40
CHEMBL3143713 1 4.30
CHEMBL3143714 1 4.10
CHEMBL342980 1 -
CHEMBL147162 1 -
CHEMBL3143717 1 -
CHEMBL146212 1 -
CHEMBL3143715 1 -
CHEMBL3143711 1 -
CHEMBL3143716 1 -
CHEMBL147862 1 -
CHEMBL3143712 1 -
CHEMBL3143710 1 -
CHEMBL344738 CF1743 1 -
CHEMBL144792 1 -
CHEMBL3143718 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL184 ACYCLOVIR EC50 = 40000.0 nM 4.40
CHEMBL3143713 EC50 = 50000.0 nM 4.30
CHEMBL3143714 EC50 = 80000.0 nM 4.10
CHEMBL342980 EC50 > 50000.0 nM -
CHEMBL147162 EC50 > 20000.0 nM -
CHEMBL3143717 EC50 >= 80000.0 nM -
CHEMBL146212 EC50 > 5000.0 nM -
CHEMBL3143715 EC50 > 20000.0 nM -
CHEMBL3143711 EC50 > 80000.0 nM -
CHEMBL3143716 EC50 > 50000.0 nM -
CHEMBL147862 EC50 > 5000.0 nM -
CHEMBL3143712 EC50 > 20000.0 nM -
CHEMBL3143710 EC50 > 200000.0 nM -
CHEMBL344738 CF1743 EC50 > 20000.0 nM -
CHEMBL144792 EC50 > 5000.0 nM -
CHEMBL3143718 EC50 > 5000.0 nM -