Assay Detail
Functional
CHEMBL834253
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Agonist activity was calculated in calcium flux assay using HEK293 cells co-transfected with human Dopamine receptor D4.4 and Galphaqo5
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.57 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362542 | — | — | 1 | 8.12 |
| CHEMBL184486 | — | — | 1 | 7.57 |
| CHEMBL185149 | — | — | 1 | 7.02 |
| CHEMBL184853 | — | — | 1 | - |
| CHEMBL183466 | — | — | 1 | - |
| CHEMBL182432 | — | — | 1 | - |
| CHEMBL184772 | — | — | 1 | - |
| CHEMBL184263 | — | — | 1 | - |
| CHEMBL183601 | — | — | 1 | - |
| CHEMBL363308 | — | — | 1 | - |
| CHEMBL185263 | — | — | 1 | - |
| CHEMBL364865 | — | — | 1 | - |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362542 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL184486 | — | EC50 | = | 26.8 | nM | 7.57 |
| CHEMBL185149 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL184853 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL183466 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL182432 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL184772 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL184263 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL183601 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL363308 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL185263 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL364865 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL54 | HALOPERIDOL | EC50 | > | 10000.0 | nM | - |