Assay Detail
Functional
CHEMBL834280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit cell proliferation in P388 tumor cell line
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.10 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70790 | — | — | 1 | 9.00 |
| CHEMBL184515 | — | — | 1 | 8.70 |
| CHEMBL186397 | — | — | 1 | 8.70 |
| CHEMBL186260 | — | — | 1 | 8.52 |
| CHEMBL361041 | — | — | 1 | 8.52 |
| CHEMBL187471 | — | — | 1 | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.00 |
| CHEMBL184236 | — | — | 1 | 8.00 |
| CHEMBL187041 | — | — | 1 | 7.52 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.40 |
| CHEMBL187426 | — | — | 1 | 7.40 |
| CHEMBL186690 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70790 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL184515 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL186397 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL186260 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL361041 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL187471 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL184236 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL187041 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL187426 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL186690 | — | IC50 | = | 110.0 | nM | 6.96 |