Assay Detail

CHEMBL834347

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibitory concentration against DU-145 prostate cancer cell proliferation over 96 hr

ChEMBL ↗

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Target

DU-145 (CHEMBL613508) ↗

Open DB target context

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Primary target DU-145

CHEMBL613508

Anchored from Assay target.

Protein identity DU-145

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	DU-145
Confidence	1 — Organism
Curated By	Expert

Target

DU-145 (CHEMBL613508) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.

Lu Q, Wang DS, Chen CS, Hu YD, Chen CS.
J Med Chem (2005) 48 : 5530 -5535
PubMed 16107152 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.53	6.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL191482	AR-42	2.0	1	6.96
CHEMBL191483	—	—	1	6.09

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL191482	AR-42	IC50	=	110.0	nM	6.96
CHEMBL191483	—	IC50	=	820.0	nM	6.09