Assay Detail
Functional
CHEMBL834457
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Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-3 adrenergic receptor
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 8.52 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183129 | — | — | 1 | 9.30 |
| CHEMBL183611 | — | — | 1 | 9.10 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 9.01 |
| CHEMBL369346 | — | — | 1 | 9.00 |
| CHEMBL183744 | — | — | 1 | 8.96 |
| CHEMBL183283 | — | — | 1 | 8.82 |
| CHEMBL434524 | — | — | 1 | 8.80 |
| CHEMBL182127 | — | — | 1 | 8.68 |
| CHEMBL183307 | — | — | 1 | 8.60 |
| CHEMBL425173 | — | — | 1 | 8.31 |
| CHEMBL181115 | — | — | 1 | 8.08 |
| CHEMBL183211 | — | — | 1 | 7.89 |
| CHEMBL183080 | — | — | 1 | 7.66 |
| CHEMBL183433 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183129 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL183611 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 0.97 | nM | 9.01 |
| CHEMBL369346 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL183744 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL183283 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL434524 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL182127 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL183307 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL425173 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL181115 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL183211 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL183080 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL183433 | — | EC50 | = | 74.0 | nM | 7.13 |