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Compound Detail

CHEMBL183744

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COc1ccccc1NC(=O)Nc1ccc(C[C@@H](CO)NC[C@H](O)COc2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL183744
Phase Preclinical
Structure Type MOL
InChI Key STRWSSNCXNGKII-VXKWHMMOSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

465.6
MW (Da)
3.27
ALogP
6
HBA
5
HBD
112.1
PSA (Ų)
0.28
QED
0
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H31N3O5
MW 465.55
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -0.86

Activity Summary

EC50 2 meas. best 8.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.96 8.96 1.1 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.92 7.92 12.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15603933 10.1016/j.bmcl.2004.11.001 Beta-3 adrenergic receptor 1
15603933 10.1016/j.bmcl.2004.11.001 Beta-1 adrenergic receptor 1
15603933 10.1016/j.bmcl.2004.11.001 Adrenergic receptor beta; ADRB1 & ADRB3 1

Data from ChEMBL 36 via Core Engine