Assay Detail
Functional
CHEMBL834455
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-1 adrenergic receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.36 | 10.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 10.08 |
| CHEMBL369346 | — | — | 1 | 9.05 |
| CHEMBL183283 | — | — | 1 | 8.89 |
| CHEMBL183307 | — | — | 1 | 8.66 |
| CHEMBL183211 | — | — | 1 | 8.52 |
| CHEMBL434524 | — | — | 1 | 8.44 |
| CHEMBL183611 | — | — | 1 | 8.40 |
| CHEMBL183744 | — | — | 1 | 7.92 |
| CHEMBL182127 | — | — | 1 | 7.82 |
| CHEMBL183129 | — | — | 1 | 7.70 |
| CHEMBL425173 | — | — | 1 | 7.57 |
| CHEMBL181115 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 0.084 | nM | 10.08 |
| CHEMBL369346 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL183283 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL183307 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL183211 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL434524 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL183611 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL183744 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL182127 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL183129 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL425173 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL181115 | — | EC50 | = | 51.0 | nM | 7.29 |